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KMID : 1202020100030020111
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Journal of Korean Thyroid Association
2010 Volume.3 No. 2 p.111 ~ p.115
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Clinical Characteristics of Papillary Thyroid Cancer in Korea
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Kim Kwang-Won
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Abstract
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The prevalence of thyroid nodule has been reported to be from 13 to 67% in the world and from 14 to 41% in Korea. Oh et al. (2010) reported that solid thyroid nodules were found in 39%. The prevalence of thyroid cancer was 2.5% among total subjects, and 6.5% among the subjects with thyroid nodules. The prevalence of papillary thyroid carcinoma (PTC) has increased, but the prevalence of follicular thyroid carcinoma and anaplastic thyroid carcinoma has decreased in Korea between 1980’s and 2000’s. The prevalence of BRAF mutations were reported to be 66∼83% in Korean PTC. The prevalence of ret/PTC rearrangement was 13%, but ras mutations were not detected. Jung et al. (2010) compared the clinicopathologic characteristics of 1,139 papillary thyroid microcarcinoma (PTMC) with those of 1,296 PTC more than 1 cm. Aggressiveness was less frequent in patients with PTMC, but recurrence and mortality rates for PTMC were also significantly lower than those of PTC (p＜0.05). The prevalence of PTC variants in Korea was 6.7% and it was much lower than previously reported. The disease-specific survival and recurrence-free survival in classic PTC were not different from those of the favorable variants, but they were higher than those of the aggressive variants (p＜0.01).
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KEYWORD
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Thyroid nodule, Papillary thyroid carcinoma, Oncogene, Variant
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